Forty‐eight pretreated osteosarcoma biopsies, including 26 whole‐section cases and 22 tumours on tissue microarrays, and 36 non‐osteogenic bone sarcomas were evaluated. Forty‐five of 48 (94%) osteosarcomas showed nuclear immunoreactivity for SATB2 (all whole‐slide sections showed expression).

The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for os-teosarcoma patients. Key Words: Cancer stem cells, Chemoresistance, Metformin, N-cadherin, Osteosarcoma, SATB2, Tumorigenesis. SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma Creytens, David MD, PhD *,† Author Information The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin: Results of a Pathology-Based Clinical Prospective Study. Am J Clin Pathol.

Satb2 osteosarcoma

2012-05-16 · Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:119540]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of Osteosarcoma and Its Variants Osteosarcomas (also known as osteogenic sarcoma) are malignant neoplasms of bone that are composed of proliferating cells that produce osteoid, at least focally. Since the production of osteoid is quite focal, it may not be recognized, in biopsies with limited sampling. High SATB2 expression in osteosarcoma patient samples was associated with poor clinical outcome.

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.

It is relatively rare among domestic animals, but corresponds to 85% of all malignant bone tumors in dogs. To study canine osteosarcoma in animals living in Brazil Apr 15, 2021 Primary bone cancer is cancer that forms in cells of the bone.

Title:Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-mediated EMT VOLUME: 19 ISSUE: 14 Author(s):Xuefeng Liu, Yonggang Fan, Jing Xie, Li Zhang, Lihua Li* and Zhenyuan Wang*

• Small cell osteosarcoma.

Anticancer Agents Med Chem. 2019 Jul 5. doi: 10.2174/1871520619666190705121614. [Epub ahead of print] Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-Mediated EMT. CONCLUSIONS: SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth.
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Ewing sarcoma (may be in differential with small cell osteosarcoma): Negative for SATB2 Contains a characteristic gene rearrangement (EWSR1-ETS transcription factor) Osteochondroma (may be in differential with parosteal osteosarcoma): Bone contiguous with native marrow Osteosarcoma (OS) is the most common malignant bone tumor and the majority of recurrences are due to metastasis. However, the molecular mechanisms that regulate OS metastatic spread are largely SATB2 positivity was present in 30/50 (60%) cases lacking osteosarcoma, predominantly as patchy moderate staining within undifferentiated sarcoma. No cases showed SATB2 positivity in chondrosarcoma or rhabdomyosarcoma components. 2012-05-16 · Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:119540].

SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for osteosarcoma patients. Conclusion: SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions. SATB2 is commonly expressed in osteosarcomas.
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High SATB2 expression in osteosarcoma patient samples was associated with poor clinical outcome. N-cadherin was one critical downstream target gene of SATB2 that mediated the stem cell-like phenotype. Reduction of SATB2 or N-cadherin resulted in NF-kB inactivation, which led to impaired osteosarcoma sphere formation and tumor cell proliferation.

Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. SATB2 is a highly sensitive marker for osteosarcomatous differentiation in gynecologic tract carcinosarcoma, and is also highly specific when used to differentiate osteosarcoma from chondrosarcoma and rhabdomyosarcoma elements in these tumors. The sensitivity of SATB2 for osteosarcoma was 94%, and the specificity was 55%.

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2020-01-31 · The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma. Ying T(1), Dong JL(2), Yuan C(1), Li P(2), Guo Q(1). Author information: (1)Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, No.10 ChangjiangZhi Road, Yuzhong District, Chong

Our aim was to investigate SATB2 expression in oral osteosarcoma and other bone-producing oral tumors/reactive lesions to evaluate its usefulness as a diagnostic marker. Forty‐eight pretreated osteosarcoma biopsies, including 26 whole‐section cases and 22 tumours on tissue microarrays, and 36 non‐osteogenic bone sarcomas were evaluated.

Apr 15, 2021 Osteosarcoma and undifferentiated pleomorphic sarcoma (UPS) (formerly called malignant fibrous histiocytoma [MFH]) of bone treatment

Conclusions Accurate diagnosis of low-grade osteosarcoma should be based on combination of clinical presentation, imaging and histopathology, with immunohistochemistry as a diagnostic adjunct. SATB2 showed 100% sensitivity (10/10) and 60% (6/10) specificity in discriminating classic osteosarcoma from osteosarcoma mimics.